Exploring the use of rigid 18-membered macrocycles with amide pendant arms for Pb(<scp>ii</scp>)-based radiopharmaceuticals
Charlene Harriswangler, Brooke L. McNeil, Isabel Brandariz-Lendoiro, Fátima Lucio‐Martínez, Laura Valencia, David Esteban‐Gómez, Caterina F. Ramogida, Carlos Platas‐Iglesias
Abstract
Large 18-membered macrocycles functionalised with amide pendants show great potential for the complexation of Pb( ii ) radioisotopes, particularly when incorporating rigid cyclohexyl units into the macrocyclic scaffold.
Topics & Concepts
AmideChemistryCombinatorial chemistryChelationPolymer chemistryStereochemistryOrganic chemistryRadiopharmaceutical Chemistry and ApplicationsChemical Reactions and IsotopesChemical Synthesis and Analysis