Development of a Commercial Process for Odalasvir
Duc N. Tran, Alexander Zhdanko, Santiago Barroso, Patrick Nieste, Ramdane Rahmani, Jan Holan, Roel Hoefnagels, Peter Reniers, Frederik Vermoortele, Stewart Duguid, Lionel Cazanave, Marek Figlus, Colin Muir, A. Clare Elliott, Peichao Zhao, Warren Paden, Cristina Hernández Díaz, Stephen Bell, Akihiro Hashimoto, Avinash Phadke, Jason A. Wiles, Ilse Vogels, Vittorio Farina
Abstract
Odalasvir is a selective inhibitor of hepatitis C virus NS5A protein, a key target for combination therapies. This paper describes the chemical process development for the synthesis of this active pharmaceutical ingredient and the improvements that were achieved over the medicinal chemistry route. Optimization of all of the reaction conditions and crystallizations resulted in higher throughput and a highly improved process mass intensity. The process is robust and has been scaled up to ∼100 kg batches without issues.