Carbonic anhydrase IX-targeted nanovesicles potentiated ferroptosis by remodeling the intracellular environment for synergetic cancer therapy
Nian Liu, Qian Lin, Wenbao Zuo, Weibin Chen, Shan Huang, Yinshu Han, Xing‐Jie Liang, Xuan Zhu, Shuaidong Huo
Abstract
for enhanced photodynamic therapy, which in turn favored LPO accumulation to synergize ferroptosis. This study presents a promising paradigm for designing nanomedicines to heighten ferroptosis-based synergetic therapeutics through remodeling the intracellular environment.
Topics & Concepts
IntracellularCarbonic anhydraseChemistryLipid peroxidationCell biologyTumor hypoxiaCancer researchBiochemistryBiologyEnzymeMedicineInternal medicineRadiation therapyNanoplatforms for cancer theranosticsFerroptosis and cancer prognosisAdvanced Nanomaterials in Catalysis