Neuroprotective effects of minocycline and KML29, a potent inhibitor of monoacylglycerol lipase, in an experimental stroke model: a small-animal positron emission tomography study
Tomoteru Yamasaki, Akiko Hatori, Yiding Zhang, Wakana Mori, Yusuke Kurihara, Masanao Ogawa, Hidekatsu Wakizaka, Jian Rong, Lu Wang, Steven H. Liang, Ming‐Rong Zhang
Abstract
PET imaging allowed visualization of the different neuroprotective effects of minocycline and KML29, and indicated that combination pharmacotherapy using these drugs may be an effective therapy in acute ischemia.
Topics & Concepts
Translocator proteinNeuroprotectionMedicineMonoacylglycerol lipaseNeuroinflammationPharmacologyPositron emission tomographyMinocyclineAnesthesiaEndocannabinoid systemInternal medicineNuclear medicineInflammationChemistryBiochemistryAntibioticsReceptorCannabis and Cannabinoid ResearchNeuroscience and Neuropharmacology ResearchSleep and Wakefulness Research