Daidzein alleviates doxorubicin-induced heart failure <i>via</i> the SIRT3/FOXO3a signaling pathway
Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang
Abstract
. Additionally, DAI can exert an antioxidant function and alleviate HF through the SIRT3/FOXO3a pathway. In conclusion, we demonstrate that DAI alleviates DOX-induced cardiotoxicity by regulating cardiac energy metabolism as well as reducing inflammation, oxidative stress, apoptosis and fibrosis, indicating its potential application for HF treatment.
Topics & Concepts
Heart failureMedicineOxidative stressCardiotoxicityCardiac function curveInflammationEjection fractionFibrosisPharmacologyCardiac fibrosisInternal medicineDoxorubicinEndocrinologyDaidzeinHeart failure with preserved ejection fractionBreast cancerCancerChemotherapyGenisteinChemotherapy-induced cardiotoxicity and mitigationSirtuins and Resveratrol in MedicineCardiovascular Function and Risk Factors