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Genomic analysis reveals a rapid spread and predominance of lambda (C.37) SARS‐COV‐2 lineage in Peru despite circulation of variants of concern

Carlos Padilla, Víctor Jimenez‐Vasquez, Verónica Hurtado, Orson Mestanza, Iris S. Molina, Luis Barcena, Sandra Morales Ruiz, Steve Acedo, Wendy Lizarraga, Henri Bailón, Omar Cáceres, Marco Galarza, Nancy Rojas, Natalia Vargas‐Herrera, Priscila Lope‐Pari, Joseph Huayra, Lely Solari

2021Journal of Medical Virology60 citationsDOIOpen Access PDF

Abstract

The pandemic generated by SARS-Cov-2 has caused a large number of cases and deaths in the world, but South America has been one of the continents that were most hard hit. The appearance of new variants causes concern because of the possibility that they may evade the protection generated by vaccination campaigns, their greater capacity to be transmitted, or their higher virulence. We analyzed the circulating variants in Peru after improving our Genomic Surveillance program. The results indicate a steep increase of the lambda lineage (C.37) until becoming predominant between January and April 2021, despite the cocirculation of other variants of concern or interest. Lambda lineage deserves close monitoring and could probably become a variant of concern in the near future.

Topics & Concepts

Lineage (genetic)PandemicVirologyVirulenceBiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)GeneticsEvolutionary biologyGeneMedicineInfectious disease (medical specialty)DiseasePathologySARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesSARS-CoV-2 detection and testing