Structure-based discovery of pyrazole-benzothiadiazole hybrid as human HPPD inhibitors
Jin Dong, Han Xiao, Jianan Chen, Bai-Feng Zheng, Yu-Ling Xu, Mengxi Chen, Wen‐Chao Yang, Hong‐Yan Lin, Guang‐Fu Yang
Topics & Concepts
Ligand (biochemistry)DruggabilityTyrosineCatabolismGatingToxicityHelix (gastropod)ChemistryBiochemistryStereochemistryBiologyMetabolismBiophysicsReceptorEcologySnailOrganic chemistryGeneBiochemical and Molecular ResearchMetal-Catalyzed Oxygenation MechanismsPharmacogenetics and Drug Metabolism