Rhabdomyolysis and severe biphasic disturbance of calcium homeostasis secondary to COVID-19 infection
Adrian Po Zhu Li, Stephen Thomas, Refik Gökmen, Dulmini Kariyawasam
Abstract
We report a case of severe hypercalcaemia secondary to rhabdomyolysis in a woman with COVID-19 (SARS CoV-2) infection. The patient presented with myalgia and anuria with an acute kidney injury requiring haemodialysis. Creatine kinase peaked at 760 000 IU/L. A biphasic calcaemic response was observed with initial severe hypocalcaemia followed by severe, symptomatic hypercalcaemia, persistent despite haemodialysis. Control of the calcium levels was achieved by continuous haemofiltration.
Topics & Concepts
RhabdomyolysismyalgiaHypercalcaemiaHypocalcaemiaMedicineCreatine kinaseCoronavirus disease 2019 (COVID-19)Acute kidney injuryInternal medicineAnuriaCalciumAnesthesiaGastroenterologyInfectious disease (medical specialty)DiseaseMuscle and Compartmental DisordersInflammatory Myopathies and DermatomyositisBone and Joint Diseases