Antibiotic Resistance Patterns and Molecular Characterization of Streptococcus suis Isolates from Swine and Humans in China
Changzhen Wang, Min-Ge Wang, Yue-Fei Chu, Ruan-Yang Sun, Jianguo Li, Xianan Li, Jian Sun, Ya-Hong Liu, Yu‐Feng Zhou, Xiao‐Ping Liao
Abstract
S. suis is a serious zoonotic pathogen. In this study, we investigated the epidemiological and molecular characteristics of 96 S. suis isolates from 10 different provinces of China from 2008 to 2019. A subset of these isolates (10) carried ICEs that were able to be horizontally transferred among isolates of different S. suis serotypes. A mouse thigh infection model revealed that ICE-facilitated ARG transfer promoted resistance development. S. suis requires continuous monitoring, especially for the presence of ICEs and associated ARGs that can be transferred via conjugation.
Topics & Concepts
Streptococcus suisBiologySerotypeTetracyclineAntibiotic resistanceMicrobiologyGenotypeDrug resistanceAntibioticsPhylogenetic treeVirologyGeneticsGeneVirulenceStreptococcal Infections and TreatmentsAntimicrobial Resistance in StaphylococcusNeonatal and Maternal Infections