RETRACTED: m6A demethylase FTO suppresses pancreatic cancer tumorigenesis by demethylating PJA2 and inhibiting Wnt signaling
Juan Zeng, Heying Zhang, Yonggang Tan, Zhe Wang, Yunwei Li, Xianghong Yang
Abstract
), thereby reducing its mRNA decay, suppressing Wnt signaling, and ultimately restraining the proliferation, invasion, and metastasis of pancreatic cancer cells. Altogether, this study describes new, potential molecular therapeutic targets for pancreatic cancer that could pave the way to improve patient outcome.
Topics & Concepts
Pancreatic cancerWnt signaling pathwayCancer researchMetastasisCarcinogenesisDemethylaseCancerUbiquitin ligaseBiologyInternal medicineFrizzledMedicineOncologySignal transductionUbiquitinEpigeneticsCell biologyGeneGeneticsRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation