N-acetylglucosaminyltransferase-V (GnT-V)-enriched small extracellular vesicles mediate N-glycan remodeling in recipient cells
Tetsuya Hirata, Yoichiro Harada, Koichiro M. Hirosawa, Yuko Tokoro, Kenichi Suzuki, Yasuhiko Kizuka
Abstract
-glycan structures of recipient cells were remodeled to express GnT-V-produced glycans. Our results suggest GnT-V-enriched sEVs' role in glycan remodeling in cancer metastasis.
Topics & Concepts
GlycanGlycosyltransferaseCancer cellBiochemistryExtracellularExtracellular vesiclesMicrovesiclesBiologyGlycomeCell biologyCancerChemistryEnzymeGeneGlycoproteinmicroRNAGeneticsExtracellular vesicles in diseaseGalectins and Cancer BiologyRNA Interference and Gene Delivery