Detection of cefiderocol and aztreonam/avibactam resistance in epidemic <i>Escherichia coli</i> ST-361 carrying <i>bla</i> <sub>NDM-5</sub> and <i>bla</i> <sub>KPC-3</sub> from foreign fighters evacuated from Ukraine
Melissa J. Martin, Ting L. Luo, Valentyn Kovalchuk, Viacheslav Kondratiuk, Henry D. Dao, Iryna Kovalenko, Brandon J. Plaza, Joanna M. Kettlewell, Cole Anderson, Jason R. Smedberg, Ana Ong, Yoon I. Kwak, Joshua S. Hawley-Molloy, Jason W. Bennett, Patrick McGann, François Lebreton
Abstract
ABSTRACT Genomic surveillance detected clonal Escherichia coli sequence type-361 isolates carrying bla NDM-5 , bla KPC-3 , bla CTX-M-15 , and rmtB1 from a patient in Ukraine and four wounded foreign soldiers evacuated to Germany. Isolates were non-susceptible to carbapenems, aminoglycosides, and cefiderocol and aztreonam/avibactam due to a PBP3 YRIN insertion and the bla CMY-145 AmpC β-lactamase. Coordinated surveillance efforts across civilian, military, and veteran healthcare systems are essential to prevent further spread as international volunteers return home after medical evacuation from Ukraine.