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A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA

Niklas Freund, Alexander I. Taylor, Sebastian Arangundy‐Franklin, Nithya Subramanian, Sew‐Yeu Peak‐Chew, Amy M. Whitaker, Bret Freudenthal, Mikhail Abramov, Piet Herdewijn, Philipp Holliger

2022Nature Chemistry57 citationsDOIOpen Access PDF

Topics & Concepts

RNAChemistryNucleic acidPolymeraseRibozymeDNADeoxyribozymeSteric effectsBiochemistryStereochemistryGeneRNA and protein synthesis mechanismsCRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry
A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA | Litcius