Electrochemical <i>N</i>-sulfonylation of <i>in situ</i> generated indole-based hydrazones and antimicrobial evaluation
Parmjeet Kaur, Anuj Kumar, Tashi Palmo, Kuljit Singh, Vikas Tyagi
Abstract
, with 5d being the most potent (MIC = 6.87 μM), while showing only moderate activity against Gram-negative pathogens. Furthermore, scanning electron microscopy (SEM) analysis revealed that the most promising hit (5d) causes significant morphological alterations and exerts its effects by causing considerable cellular damage.
Topics & Concepts
ChemistryElectrochemistryCombinatorial chemistryRegioselectivityCyclic voltammetryAntimicrobialAntibacterial activityChemical synthesisAntibacterial agentSodiumNuclear chemistryHydrazoneOrganic chemistryReaction mechanismVoltammetryStereochemistryStructure–activity relationshipSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsRadical Photochemical Reactions