Enantioselective dearomative formal (3+3) cycloadditions of bicyclobutanes with aromatic azomethine imines: access to fused 2,3-diazabicyclo[3.1.1]heptanes
Xue-Chun Yang, Feng Wu, Wen‐Biao Wu, Xu Zhang, Jian‐Jun Feng
Abstract
We present the first enantioselective dearomative (3+3) cycloadditions of bicyclobutanes (BCBs) utilizing a chiral Lewis acid catalyst and bidentate chelating BCB substrates.
Topics & Concepts
Enantioselective synthesisCatalysisChelationChemistryDenticityLewis acids and basesCombinatorial chemistryOrganic chemistryCrystal structureCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions