Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors
Moriah R. Arnold, Marie-France Langelier, Jessica Gartrell, Ilsa T. Kirby, Daniel J. Sanderson, Daniel S. Bejan, Justina Šileikytė, Sunil K. Sundalam, Shanthi Nagarajan, Parthiban Marimuthu, Anna K. Duell, Anang A. Shelat, John M. Pascal, Michael S. Cohen
Topics & Concepts
Allosteric regulationCytotoxicityPoly ADP ribose polymeraseNAD+ kinasePARP inhibitorDNAChemistryDNA replicationBinding siteBiochemistryBiologyCell biologyStereochemistryIn vitroEnzymePolymerasePARP inhibition in cancer therapyIntegrated Circuits and Semiconductor Failure AnalysisDNA Repair Mechanisms