α-Ketoglutaric acid ameliorates intervertebral disk degeneration by blocking the IL-6/JAK2/STAT3 pathway
Hao-Wei Xu, Xin‐Yue Fang, Xiaowei Liu, Shu‐Bao Zhang, Yu‐Yang Yi, Sheng-Jie Chang, Hao Chen, Shan‐Jin Wang
Abstract
Alpha-ketoglutaric acid (α-KG) exerted its protective effect on nucleus pulposus cells' (NPCs) degeneration by inhibiting the senescence-associated secretory phenotype and extracellular matrix degradation. The possible mechanism may be associated with negatively regulating the JAK2/STAT3 phosphorylation and the decreased IL-6 expression, which could be explained by a blockage of the positive feedback control loop between IL-6 and JAK2/STAT3 pathway.
Topics & Concepts
PhosphorylationSTAT3Cell biologySenescenceExtracellular matrixApoptosisBiologyIntervertebral discDegeneration (medical)MedicineBiochemistryPathologyAnatomySpine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationPlant Toxicity and Pharmacological Properties