Palladium-Catalyzed Cross-Electrophile Couplings of Aryl Thianthrenium Salts with Aryl Bromides via C–S Bond Activation
Qian-Qian Fu, Yuan Liang, Xiaoxiao Sun, Xue‐Qiang Chu, Hao Xu, Xiaocong Zhou, Weidong Rao, Zhi‐Liang Shen
Abstract
We report here a step-economic and cost-effective cross-electrophile coupling of aryl thianthrenium salts with widely available aryl bromides, which proceeded effectively via C-S bond activation at ambient temperature in THF in the presence of a palladium catalyst, magnesium turnings, and lithium chloride to enable the facile assembly of a wide array of structurally diverse biaryls in modest to good yields with good functional group compatibility. In addition, the gram-scale reaction could also be realized.
Topics & Concepts
ChemistryArylPalladiumElectrophileCatalysisMedicinal chemistryCombinatorial chemistryOrganic chemistryAlkylCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesCatalytic Cross-Coupling Reactions