Prochlorperazine enhances radiosensitivity of non-small cell lung carcinoma by stabilizing GDP-bound mutant KRAS conformation
Kirti Sad, Palak Parashar, Pragya Tripathi, Hungharla Hungyo, Ramesh Sistla, Ravi Soni, Vibha Tandon
Topics & Concepts
KRASCancer researchRadioresistanceRadiosensitizerRadiosensitivityChemistryLung cancerA549 cellMutantCell cycle checkpointCancerCell cycleApoptosisPharmacologyMedicineInternal medicineRadiation therapyBiochemistryColorectal cancerGeneCell death mechanisms and regulationProtein Kinase Regulation and GTPase SignalingCancer-related Molecular Pathways