Azoreductase-triggered fluorescent nanoprobe synthesized by RAFT-mediated polymerization-induced self-assembly for drug release
Yechun Zhou, Zhe Wang, Yuqing Wang, Lishan Li, Nianchen Zhou, Yuanli Cai, Zhengbiao Zhang, Xiulin Zhu
Abstract
Herein, micelles loaded with doxorubicin (DOX) <italic>in situ</italic> were synthesized by polymerization-induced self-assembly. Furthermore, the DOX-loaded micelles showed release and fluorescence change, owing to azoreductase-triggered azo bond cleavage.
Topics & Concepts
MicelleRaftPolymerizationFluorescenceChemistryNanoprobeReversible addition−fragmentation chain-transfer polymerizationPolymer chemistryCopolymerDoxorubicinPhotochemistryBiophysicsRadical polymerizationOrganic chemistryPolymerAqueous solutionSurgeryChemotherapyBiologyQuantum mechanicsMedicinePhysicsLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsSupramolecular Self-Assembly in Materials