VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis
Pingcui Xu, Bingfeng Lin, Xuehui Deng, Kai Huang, Yan Zhang, Nani Wang
Topics & Concepts
Calcitriol receptorOsteoblastGPX4ChemistrySenescenceGene knockdownCell biologyLipid peroxidationPhospholipid-hydroperoxide glutathione peroxidaseCancer researchInternal medicineEndocrinologyOxidative stressBiologyGlutathione peroxidaseBiochemistryReceptorApoptosisIn vitroMedicineSuperoxide dismutaseBone Metabolism and DiseasesDigestive system and related healthGDF15 and Related Biomarkers