Dietary tangeretin improved antibiotic-associated diarrhea in mice by enhancing the intestinal barrier function, regulating the gut microbiota, and metabolic homeostasis
Bin Chen, Xun Yang, Minmin Zhan, Yilu Chen, Jingyi Xu, Jie Xiao, Hang Xiao, Mingyue Song
Abstract
. Additionally, dietary tangeretin restored the levels of short-chain fatty acids and modulated metabolic pathways by enriching purine metabolism, bile acid metabolism, ABC transporters, and choline metabolism in cancer. Collectively, these findings provide a solid scientific basis for the rational use of tangeretin as a preventive and therapeutic agent for antibiotic-associated diarrhea.
Topics & Concepts
Gut floraBarrier functionDiarrheaAntibioticsHomeostasisFunction (biology)MicrobiologyBiologyImmunologyCell biologyMedicineInternal medicineBioactive Compounds in PlantsGinger and Zingiberaceae researchPharmacological Effects of Natural Compounds