Population Pharmacokinetics and Target Attainment of Cefepime in Critically Ill Patients and Guidance for Initial Dosing
Mohammad H. Al‐Shaer, Michael Neely, Jiajun Liu, Kartikeya Cherabuddi, Veena Venugopalan, Nathaniel J. Rhodes, Kenneth Klinker, Marc H. Scheetz, Charles A. Peloquin
Abstract
Cefepime is commonly used in the intensive care unit (ICU) to treat bacterial infections. The time during which the free cefepime concentration is above the MIC ( f T >MIC ) should be optimized to increase the efficacy of the regimen. We aim to optimize the exposure of cefepime in ICU patients by using population pharmacokinetic (PK) modeling and simulations. Two data sets were included in this study. The first was a prospective study of pediatric patients who received cefepime at 50 mg/kg of body weight and had extensive PK sampling.
Topics & Concepts
CefepimeMedicineDosingPharmacokineticsIntensive care unitPopulationRegimenTherapeutic drug monitoringIntensive care medicinePharmacologyInternal medicineAntibioticsBiologyMicrobiologyImipenemAntibiotic resistanceEnvironmental healthAntibiotics Pharmacokinetics and EfficacyPneumonia and Respiratory InfectionsSepsis Diagnosis and Treatment