Radical Heteroarylalkylation of Alkenes via <scp>Three‐Component Docking‐Migration</scp> Thioetherification Cascade
Tao Niu, Jige Liu, Xinxin Wu, Chen Zhu
Abstract
Summary of main observation and conclusion A novel, rational‐designed approach to access various heteroaryl‐substituted alkyl thioethers was developed via docking‐migration cascade process. By utilizing three components involving alkene, dual‐function reagent, and thioetherificating reagent, radical heteroarylalkylation of alkenes followed by thiolation of the alkyl radical intermediates proceeded smoothly, manifesting well compatibility of substrates and cascade transformations. Furthermore, this protocol also features mild conditions, broad substrate scope, and wide product diversity.
Topics & Concepts
ChemistryCascadeAlkeneReagentAlkylDocking (animal)Combinatorial chemistryCompatibility (geochemistry)StereochemistryOrganic chemistryCatalysisChemical engineeringMedicineEngineeringNursingChromatographySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsRadical Photochemical Reactions