Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway
Minfang Guo, Huiyu Zhang, Yanhua Li, Qingfang Gu, Wenyue Wei, Yu-yin Wang, Xiaojuan Zhang, Xiaoqin Liu, Lijuan Song, Zhi Chai, Jiezhong Yu, Cun‐Gen Ma
Topics & Concepts
MicrogliaFasudilAstrocyteNeuroinflammationNeuroprotectionTLR4Downregulation and upregulationGenetically modified mousePhenotypeInflammationTransgeneCell biologyNeuroscienceChemistryPharmacologyBiologyImmunologySignal transductionCentral nervous systemRho-associated protein kinaseBiochemistryGeneNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments