Interplay between Candida albicans and Lactic Acid Bacteria in the Gastrointestinal Tract: Impact on Colonization Resistance, Microbial Carriage, Opportunistic Infection, and Host Immunity
Karen D. Zeise, Robert J. Woods, Gary B. Huffnagle
Abstract
Emerging studies have highlighted the disproportionate role of Candida albicans in influencing both early community assembly of the bacterial microbiome and dysbiosis during allergic diseases and intestinal inflammation. Nonpathogenic colonization of the human gastrointestinal (GI) tract by C. albicans is common, and the role of this single fungal species in modulating bacterial community reassembly after broad-spectrum antibiotics can be readily recapitulated in mouse studies.
Topics & Concepts
MicrobiologyCandida albicansBiologyCorpus albicansEnterococcus faecalisVirulenceColonizationMicrobiomeBacteriaDysbiosisAntibioticsGastrointestinal tractCommensalismImmune systemImmunityHuman microbiomeHuman gastrointestinal tractHost (biology)AntimicrobialEnterococcusPathogenic bacteriaBiofilmLactobacillusInnate immune systemColonisationGut microbiota and healthProbiotics and Fermented FoodsAntifungal resistance and susceptibility