Potential use of polyphenols in the battle against COVID-19
Ines L. Paraiso, Johana S. Revel, Jan F. Stevens
Abstract
The coronavirus disease 2019 (COVID-19) is a public health emergency of international concern. The rising number of cases of this highly transmissible infection has stressed the urgent need to find a potent drug. Although repurposing of known drugs currently provides an accelerated route to approval, there is no satisfactory treatment. Polyphenols, a major class of bioactive compounds in nature, are known for their antiviral activity and pleiotropic effects. The aim of this review is to assess the effects of polyphenols on COVID-19 drug targets as well as to provide a perspective on the possibility to use polyphenols in the development of natural approaches against this viral disease.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)PolyphenolDrug repositioningSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)RepurposingDrug2019-20 coronavirus outbreakBattleCoronavirusPharmacologyMedicineDiseaseInfectious disease (medical specialty)Intensive care medicineBiologyVirologyAntioxidantBiochemistryInternal medicineHistoryEcologyArchaeologyOutbreakComputational Drug Discovery MethodsPharmacological Effects of Natural CompoundsNigella sativa pharmacological applications