Terpyridine copper(<scp>ii</scp>) complexes as potential anticancer agents by inhibiting cell proliferation, blocking the cell cycle and inducing apoptosis in BEL-7402 cells
Yun‐Qiong Gu, Yu-Jun Zhong, Mei‐Qi Hu, Huanqing Li, Kun Yang, Qi Dong, Hong Liang, Zhen‐Feng Chen
Abstract
release and the activation of the caspase cascade, and induced mitochondrion-mediated apoptosis. Animal studies demonstrated that complex 1 suppressed tumor growth in a mouse xenograft model bearing BEL-7402 tumor cells.
Topics & Concepts
ApoptosisChemistryCell cycleIntracellularMitochondrionCell growthCytochrome cCytotoxicityCytotoxic T cellCell biologyCancer cellCell cycle checkpointCellCell cultureMembrane potentialCaspaseProgrammed cell deathCisplatinBiochemistryBiologyIn vitroCancerChemotherapyGeneticsMetal complexes synthesis and propertiesTrace Elements in HealthMetal-Catalyzed Oxygenation Mechanisms