Targeting PI3Kα overcomes resistance to KRasG12C inhibitors mediated by activation of EGFR and/or IGF1R
Wei-liang Qi, Huiyu Li, Yi Wang, Lan Xu, Jie-ting Deng, Xi Zhang, Yuxiang Wang, Linghua Meng, Yuxiang Wang, Linghua Meng
Topics & Concepts
Insulin-like growth factor 1 receptorPI3K/AKT/mTOR pathwayMAPK/ERK pathwayProtein kinase BReceptor tyrosine kinasePharmacologyCancer researchKinaseSignal transductionMedicineReceptorCell biologyBiologyInternal medicineGrowth factorProtein Kinase Regulation and GTPase SignalingCancer-related Molecular PathwaysMelanoma and MAPK Pathways