Interaction Between Serum/Glucocorticoid-Regulated Kinase 1 and Interleukin-6 in Chronic Rhinosinusitis
Yuting Lai, Li Hu, Yang Lu, Xianting Hu, Xiaole Song, Jingyi Yang, Hongbin Li, Kun Chen, Huabin Li, Dehui Wang
Abstract
PURPOSE: Serum/glucocorticoid-regulated kinase 1 (SGK1) has recently emerged as a critical regulator of inflammatory diseases. In this study, we examined SGK1 expression and its possible pathogenic roles in chronic rhinosinusitis (CRS). METHODS: . RESULTS: < 0.05). Administration of GSK650394, a SGK1 inhibitor, significantly increased IL-6 self-induced mRNA expression in cultured dispersed NP cells and 16HBE cells. CONCLUSIONS: The interaction between SGK1 and IL-6 may play an anti-inflammatory role in IL-6-induced inflammation in the pathogenesis of CRS.
Topics & Concepts
SGK1Gene knockdownNasal polypsLamina propriaMolecular biologyKinaseGlucocorticoidA549 cellMessenger RNAMedicineInterleukin 8BiologyCellCell cultureInflammationImmunologyPathologyEpitheliumCell biologyGeneBiochemistryGeneticsSinusitis and nasal conditionsInfectious Diseases and MycologyHead and Neck Surgical Oncology