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Design, synthesis, biological evaluation and in silico studies of EGFR inhibitors based on 4-oxo-chromane scaffold targeting resistance in non-small cell lung cancer (NSCLC)

Kshipra S. Karnik, Aniket P. Sarkate, Shailee V. Tiwari, Rajaram Azad, Pravin S. Wakte

2022Medicinal Chemistry Research16 citationsDOI

Topics & Concepts

ChemistryIn silicoT790MIC50CytotoxicityEGFR inhibitorsIn vitroKinaseEnzymeBiochemistryDPPHCombinatorial chemistryPharmacologyCancer researchEpidermal growth factor receptorAntioxidantBiologyReceptorGeneGefitinibSynthesis and biological activityCancer therapeutics and mechanismsLung Cancer Treatments and Mutations
Design, synthesis, biological evaluation and in silico studies of EGFR inhibitors based on 4-oxo-chromane scaffold targeting resistance in non-small cell lung cancer (NSCLC) | Litcius