Human milk oligosaccharide 2′-fucosyllactose alleviates cognitive impairment <i>via</i> the vagal afferent pathway in Alzheimer's disease mice
Mengzhen Jia, Xiaorui Wang, Fangjie Ning, Wenxiu Wang, Xinyu Hu, Kexin Geng, Junqing Wen, Shan Wu, Bin Wang, Zhigang Liu
Abstract
, and others. Moreover, 2'-FL promoted the production of short-chain fatty acids (SCFAs). Correlation analysis showed that propionate was highly correlated with other related indicators. After vagotomy, although 2'-FL promoted SCFA production, it did not alleviate cognitive impairment. This suggested that the neuroprotective effect of SCFAs could also be partially dependent on the VN. 2'-FL rescued the cognitive deficits in AD mice, which was partly explained by changes in gut microbial composition, production of SCFAs, and the presence of VN.
Topics & Concepts
Cognitive impairmentAfferentDiseaseMedicineNeuroscienceCognitionEndocrinologyPharmacologyInternal medicinePsychologyInfant Nutrition and HealthInfant Health and DevelopmentDigestive system and related health