Epigenetic Reprogramming of Host and Viral Genes by Human Cytomegalovirus Infection in Kasumi-3 Myeloid Progenitor Cells at Early Times Postinfection
Eleonora Forte, Fatma Ayaloglu Butun, Christian Marinaccio, Matthew J. Schipma, Andrea Piunti, Mark W. Schroeder, Manoj Kandpal, Ali Shilatifard, Michaël Abécassis, Mary Hummel
Abstract
Human cytomegalovirus (HCMV) is an important human pathogen in immunocompromised hosts and developing fetuses. Current antiviral therapies are limited by toxicity and emergence of resistant strains.
Topics & Concepts
BiologyReprogrammingVirologyHuman cytomegalovirusCytomegalovirusEpigeneticsMyeloidProgenitor cellGeneViral replicationVirusStem cellGeneticsHerpesviridaeImmunologyViral diseaseCytomegalovirus and herpesvirus researchVirus-based gene therapy researchHIV Research and Treatment