Local Efficacy of Glutamate Uptake Decreases with Synapse Size
Michel K. Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna Agnieszka Komorowska‐Müller, Stefan Passlick, Inna Schwarz, Colin J. Jackson, Dirk Dietrich, Martin K. Schwarz, Christian Henneberger
Abstract
entry is also more strongly increased by uptake inhibition. These findings indicate that spine size inversely correlates with the efficacy of local glutamate uptake and thereby likely determines the probability of synaptic crosstalk.
Topics & Concepts
Glutamate receptorSynapseNMDA receptorDendritic spineAMPA receptorAstrocyteSilent synapseNeurotransmissionNeurosciencePostsynaptic densityBiologyPostsynaptic potentialMetabotropic glutamate receptorBiophysicsChemistryHippocampal formationReceptorBiochemistryCentral nervous systemNeuroscience and Neuropharmacology ResearchNeural dynamics and brain functionPhotoreceptor and optogenetics research