Induced pluripotent stem cells-derived microvesicles accelerate deep second-degree burn wound healing in mice through miR-16-5p-mediated promotion of keratinocytes migration
Yuan Yan, Ruijun Wu, Yunyao Bo, Min Zhang, Yinghua Chen, Xueer Wang, Mianbo Huang, Baiting Liu, Lin Zhang
Abstract
Therefore, our results indicate that iPSCs-MVs-derived miR-16-5p may be a novel therapeutic approach for deep second-degree burn wound healing.
Topics & Concepts
Wound healingInduced pluripotent stem cellMicrovesiclesCell biologyBurn woundStem cellChemistryMedicineBiologymicroRNAImmunologyEmbryonic stem cellBiochemistryGeneExtracellular vesicles in diseaseWound Healing and TreatmentsElectrospun Nanofibers in Biomedical Applications