Acyl fluorides as direct precursors to fluoride ketyl radicals: reductive deuteration using SmI<sub>2</sub> and D<sub>2</sub>O
Hengzhao Li, Mengqi Peng, Zemin Lai, Ning Lei, Xingyue Chen, Xiaoxu Zhang, Pengjie Wang, Roman Szostak, Michal Szostak, Jie An
Abstract
O as the deuterium source. This method introduces acyl fluorides as attractive radical precursors for the generation of reactive acyl-type fluoride ketyls that should find widespread application in many synthetic strategies involving single electron transfer processes.
Topics & Concepts
KetylFluorideRadicalChemistryMedicinal chemistryPhotochemistryInorganic chemistryOrganic chemistryChemical Reactions and IsotopesFluorine in Organic ChemistryMass Spectrometry Techniques and Applications