Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme
Drashti G. Daraji, Dhanji P. Rajani, Smita D. Rajani, Edwin A. Pithawala, Sivaraman Jayanthi, Hitesh D. Patel
Topics & Concepts
ChemistryDihydropteroate synthaseAntimicrobialStaphylococcus aureusADMEAcetamideDocking (animal)Antibacterial activityThio-StereochemistryMicrobiologyBiochemistryIn vitroBacteriaPlasmodium falciparumOrganic chemistryBiologyNursingMedicineMalariaPyrimethamineImmunologyGeneticsBiochemical and Molecular ResearchSynthesis and biological activityHIV/AIDS drug development and treatment