A reduction and pH dual-sensitive nanodrug for targeted theranostics in hepatocellular carcinoma
Mingyue Cai, Bo Li, Liteng Lin, Jingjun Huang, Yongcheng An, Wensou Huang, Zhimei Zhou, Yong Wang, Xintao Shuai, Kangshun Zhu
Abstract
-mediated active targeting to HCC cells, the nanodrug exhibited an easy cellular uptake and enhanced tumor accumulation. The prominent reduction and pH dual-sensitivity allowed the nanodrug to rapidly release SF inside cancer cells via responding to the cytoplasmic glutathione and lysosomal acidity. The nanodrug not only significantly improved the anticancer effects of SF in hepatoma treatment but also facilitated a noninvasive tumor detection and monitoring of in vivo drug delivery by MRI, which revealed its great potential as a promising theranostic system.
Topics & Concepts
Hepatocellular carcinomaSorafenibReduction (mathematics)ChemistryDual (grammatical number)Cancer researchCarcinomaMicelleHepatic carcinomaMedicineInternal medicineMathematicsLiteratureArtAqueous solutionPhysical chemistryGeometryNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRNA Interference and Gene Delivery