Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing
Eduardo Martínez, Zaynab Hammoud, Alessandra Mara de Sousa, Frank Krämer, Rubens Lima do Monte‐Neto, Vinicius Maracaja‐Coutinho, Alberto J. M. Martín
Abstract
infection process, we both validated our work and found eight drugs already approved for use in humans that to the best of our knowledge were never employed to treat leishmaniasis, rendering our work as a new tool in the box available to the scientific community fighting parasites.
Topics & Concepts
Drug repositioningLeishmaniasisComputational biologyBiologyRepurposingLeishmaniaDrugDiseaseTranscription factorGeneMedicineImmunologyParasite hostingPharmacologyComputer scienceGeneticsEcologyPathologyWorld Wide WebResearch on Leishmaniasis StudiesTrypanosoma species research and implications