Mitochondria-targeting biocompatible fluorescent BODIPY probes
Edward R. H. Walter, Lawrence Cho‐Cheung Lee, Peter Kam‐Keung Leung, Kenneth Kam‐Wing Lo, Nicholas J. Long
Abstract
compounds demonstrated a high MMP-sensitive localisation in the mitochondria, with Pearson's correlation coefficients (PCC) of between 0.76 and 0.96. Compounds BODIPY-Mito-2 and BODIPY-Mito-6 revealed the highest sensitivity to the MMP, with a decrease in the emission intensity of 62% and 75%, respectively following MMP depolarisation. It is anticipated that the highest MMP sensitivity and enhanced biocompatibility of BODIPY-Mito-6 could lead to the development of new probes for mitochondrial imaging in the future.
Topics & Concepts
Biocompatible materialBODIPYFluorescenceMitochondrionBiophysicsChemistryNanotechnologyMaterials scienceBiochemistryMedicineBiologyBiomedical engineeringPhysicsQuantum mechanicsLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsMolecular Sensors and Ion Detection