Synthesis of 2-trifluoromethyl benzimidazoles, benzoxazoles, and benzothiazoles <i>via</i> condensation of diamines or amino(thio)phenols with CF<sub>3</sub>CN
Bo Lin, Yunfei Yao, Minze Wu, Lu Qin, Shouxiong Chen, Yi You, Zhiqiang Weng
Abstract
the nucleophilic addition of trifluoroacetonitrile to the amino group of the diamine derivatives to form an imidamide intermediate, followed by intramolecular cyclization.
Topics & Concepts
ChemistryThio-TrifluoromethylPhenolsCondensationMedicinal chemistryOrganic chemistryCombinatorial chemistryThermodynamicsAlkylPhysicsFluorine in Organic ChemistrySynthesis and Biological EvaluationSulfur-Based Synthesis Techniques