Discovery of Harmaline as a Potent Inhibitor of Sphingosine Kinase-1: A Chemopreventive Role in Lung Cancer
Sonam Roy, Taj Mohammad, Preeti Gupta, Rashmi Dahiya, Shahnaz Parveen, Suaib Luqman, Gulam Mustafa Hasan, Md. Imtaiyaz Hassan
Abstract
value in the micromolar range. The cytotoxic effect of harmaline on non-small-cell lung cancer cells by MTT assay was found to be higher for H1299 compared to A549. Harmaline induces apoptosis in non-small-cell lung carcinoma cells (H1299 and A549), possibly via the intrinsic pathway. Our findings suggest that harmaline could be implicated as a scaffold for designing potent anticancer molecules with SphK1 inhibitory potential.
Topics & Concepts
HarmalineSphingosineSphingosine kinase 1Sphingosine kinaseKinaseCancer cellPharmacologyA549 cellChemistryIC50CeramideLipid signalingBiochemistryBiologyCancer researchApoptosisSphingosine-1-phosphateEnzymeCancerIn vitroReceptorGeneticsSphingolipid Metabolism and SignalingCancer therapeutics and mechanismsCalcium signaling and nucleotide metabolism