Synergy Mechanisms of Daptomycin-Fosfomycin Combinations in Daptomycin-Susceptible and -Resistant Methicillin-Resistant Staphylococcus aureus: <i>In Vitro</i> , <i>Ex Vivo</i> , and <i>In Vivo</i> Metrics
Nagendra N. Mishra, Cassandra Lew, Wessam Abdelhady, Christian K. Lapitan, Richard A. Proctor, Warren E. Rose, Arnold S. Bayer
Abstract
< 0.05). Furthermore, preconditioning this strain pair to DAP with or without Fosfo (DAP+/-Fosfo) sensitized these organisms to killing by the human host defense peptide LL37. These data underscore the notion that DAP-Fosfo combinations can impact MRSA clearances within multiple microenvironments, likely based on specific phenotypic adaptations.
Topics & Concepts
DaptomycinStaphylococcus aureusCardiolipinPhenotypeStrain (injury)MicrobiologyBiologyBiofilmCell envelopeLipid IICellBacteriaCell membraneStaphylococcal infectionsChemistryAntibioticsVirulenceStaphylococcusCell biologyGenePeptideAntibacterial agentLipopeptideVancomycinEndocarditisMembrane proteinIn silicoAntimicrobial Resistance in StaphylococcusAntimicrobial agents and applicationsBacterial biofilms and quorum sensing