Physiology of Glymphatic Solute Transport and Waste Clearance from the Brain
Lucy Zhao, Allen Tannenbaum, Erik N.T.P. Bakker, Helene Benveniste
Abstract
This review focuses on the physiology of glymphatic solute transport and waste clearance, using evidence from experimental animal models as well as from human studies. Specific topics addressed include the biophysical characteristics of fluid and solute transport in the central nervous system, glymphatic-lymphatic coupling, as well as the role of cerebrospinal fluid movement for brain waste clearance. We also discuss the current understanding of mechanisms underlying increased waste clearance during sleep.
Topics & Concepts
Glymphatic systemCerebrospinal fluidNeuroscienceLymphatic systemPhysiologyWater transportChemistryMedicineBiologyEnvironmental sciencePathologyWater flowEnvironmental engineeringCerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular DisturbancesSpinal Dysraphism and Malformations