Analysis of the Expression of Exostosins and Clinicopathological Features in Membranous Lupus Nephritis in a Chinese Cohort
Huixian Li, Ping Lan, Xiaoyang Yu, Xiaoling Liu, Jiping Sun, Liyi Xie, Wanhong Lu, Xinfang Xie
Abstract
Exostosin 1/Exostosin 2 (EXT1/EXT2) were recently described by Sethi et al.1 as 2 new proteins and putative antigens in secondary membranous nephropathy, which were frequently associated with autoimmune findings of an underlying autoimmune disease, such as systemic lupus erythematosus (SLE) or mixed connective tissue disease. To date, limited studies have been published to validate and explore their clinical and pathological significance. In this study we aimed to evaluate the expression of EXTs, their clinicopathologic features, and the prognosis for EXT1/2–positive membranous lupus nephritis (MLN).
Topics & Concepts
MedicineLupus nephritisPathologicalMembranous nephropathyPathologyConnective tissueSystemic lupus erythematosusDiseaseImmunologyGlomerulonephritisInternal medicineKidneyCell Adhesion Molecules ResearchSystemic Lupus Erythematosus ResearchCaveolin-1 and cellular processes