The genome of the naturally evolved obesity-prone Ossabaw miniature pig
Yaolei Zhang, Guangyi Fan, Xin Liu, Kerstin Skovgaard, Michael Sturek, Peter M. H. Heegaard
Abstract
(leptin receptor) containing two positively selected sites which may lead to pseudogenization of this gene with possible significant effects on obesity and inflammation development. This work provides the first complete mapping of a genome representing a naturally 'feast and famine' evolved phenotype of MetS, serving as a blueprint to guide the search for new targets and new biomarkers for obesity comorbidities.
Topics & Concepts
ObesityGenomeBiologyComputational biologyGeneticsGeneEndocrinologyCancer-related molecular mechanisms researchGenetic Mapping and Diversity in Plants and AnimalsGenetic and phenotypic traits in livestock