Rosmarinic Acid: A Naturally Occurring Plant Based Agent Prevents Impaired Mitochondrial Dynamics and Apoptosis in Ultraviolet‐B‐Irradiated Human Skin Cells
Divya Gupta, Sajida Archoo, Shahid Hussain Naikoo, Sheikh Tasduq Abdullah
Abstract
Ultraviolet B (UVB) radiation is the leading cause of premature skin aging and skin cancer. UVB mediated mitochondrial dysfunction has been identified as one of the causative factors of UVB induced oxidative imbalance and apoptosis. Here, we report that UVB leads to mitochondrial fragmentation by causing imbalance in the markers regulating mitochondrial dynamics, which further contributes to ROS imbalance and activation of mitochondrial apoptotic signals. Several studies have demonstrated natural products as inhibitors of mitochondrial fission. However, to our knowledge, not much evidence has been gathered regarding utilization of Rosmarinic acid (RA) against UVB orchestrated mitochondrial fragmentation responses. Thus, in our study, we present the evidence of the efficacy of RA as a modulator of mitochondrial dynamics in UVB irradiated skin cells to prevent oxidative imbalance and apoptosis thereby preventing UVB induced photodamage.