Trimetazidine alleviates paclitaxel-induced peripheral neuropathy through modulation of TLR4/p38/NF-κB and klotho protein expression
Asmaa Hammad, Mohamed M. Sayed‐Ahmed, Sara Mohamed Naguib Abdel Hafez, Ahmed R. N. Ibrahim, Mohamed Mansour Khalifa, Mahmoud El‐Daly
Topics & Concepts
PharmacologyMedicinePeripheral neuropathyTLR4Trimetazidinep38 mitogen-activated protein kinasesProinflammatory cytokineResveratrolProtein kinase BApoptosisEndocrinologySignal transductionInternal medicineChemistryReceptorInflammationMAPK/ERK pathwayDiabetes mellitusBiochemistryCancer Treatment and PharmacologyPain Mechanisms and TreatmentsSilymarin and Mushroom Poisoning