Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer’s and Parkinson’s Disease
Rohan Gupta, Pravir Kumar
Abstract
: The loss of acetylated hotspot sites results in the loss of ubiquitination and SUMOylation function on nearby sites, which is relatively higher when compared to the gain of function.
Topics & Concepts
SUMO proteinAcetylationLysineHistoneUbiquitinInteractorCell biologyParkinson's diseaseChemistryDiseaseNeuroscienceCancer researchBiologyBiochemistryMedicineInternal medicineDNAAmino acidGeneHistone Deacetylase Inhibitors ResearchUbiquitin and proteasome pathwaysSignaling Pathways in Disease