<i>miR</i> - <i>218</i> - <i>2</i> regulates cognitive functions in the hippocampus through complement component 3–dependent modulation of synaptic vesicle release
Si‐Yao Lu, Chong-Lei Fu, Liang Liang, Bo Yang, Weiliang Shen, Qiu-Wen Wang, Yun Chen, Yanfen Chen, Yaonan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, Jun Yao
Abstract
Significance Several neurodegenerative and neuropsychiatric disorders with cognitive symptoms show an abnormal expression of microRNA-218 (miR-218). In this study, we demonstrated that miR-218 regulated presynaptic functions and learning related behaviors through targeting the 3′-untranslated region (UTR) of the mRNA of complement component 3 (C3), a central component of the immune system. This finding may represent a common mechanism for the defective cognition of multiple neuronal disorders with miR-218 deficits and provide a strategy for the development of new therapy.
Topics & Concepts
Complement (music)HippocampusNeuroscienceModulation (music)Component (thermodynamics)Synaptic vesiclePsychologyChemistryVesiclePhysicsGeneBiochemistryQuantum mechanicsComplementationAcousticsMembranePhenotypeNeuroinflammation and Neurodegeneration MechanismsMicroRNA in disease regulationNeurogenesis and neuroplasticity mechanisms